UPSC Mains Medical Science Syllabus

Paper - I

1. Human Anatomy: Applied anatomy including blood and nerve supply of upper and lower limbs and joints of the shoulder, hip, and knee. Gross anatomy, blood supply, and lymphatic drainage of tongue, thyroid, mammary gland, stomach, liver, prostate, gonads, and uterus. Applied anatomy of diaphragm, perineum, and inguinal region.  Clinical anatomy of kidney, urinary bladder, uterine tubes, vas deferens. Embryology: Placenta and placental barrier. Development of heart, gut, kidney, uterus, ovary, testis and their common congenital abnormalities. Central and peripheral autonomic nervous system: Gross and clinical anatomy of ventricles of the brain, circulation of cerebrospinal fluid; Neural pathways and lesions of cutaneous sensations, hearing, and vision; Cranial nerves, distribution and clinical significance; Components of the autonomic nervous system.

2. Human Physiology: Conduction and transmission of impulse, mechanism of contraction, neuromuscular transmission, reflexes, control of equilibrium, posture and muscle tone, descending pathways, functions of the cerebellum, basal ganglia, Physiology of sleep and consciousness. Endocrine system: Mechanism of action of hormones, formation, secretion, transport, metabolism, function, and regulation of secretion of pancreas and pituitary gland.  Physiology of reproductive system: Menstrual cycle, lactation, pregnancy. Blood: Development, regulation, and the fate of blood cells. Cardio-vascular, cardiac output, blood pressure, regulation of cardiovascular functions;

3. Biochemistry: Organ function tests-liver, kidney, thyroid Protein synthesis. Vitamins and minerals. Restriction fragment length polymorphism (RFLP). Polymerase chain reaction (PCR). Radioimmunoassays (RIA). 

4. Pathology: Inflammation and repair, disturbances of growth and cancer, Pathogenesis and histopathology of rheumatic and ischemic heart disease and diabetes mellitus. Differentiation between benign, malignant, primary and metastatic malignancies, Pathogenesis and histopathology of bronchogenic carcinoma, carcinoma breast, oral cancer, cancer cervix, leukemia, Etiology, pathogenesis, and histopathology of - cirrhosis liver, glomerulonephritis, tuberculosis, acute osteomyelitis.

5. Microbiology:  Humoral and cell-mediated immunity Diseases caused by and laboratory diagnosis of- l Meningococcal, Salmonella l Shigella, Herpes, Dengue, Polio l HIV/AIDS, Malaria, E. Histolytica, Giardia l Candida, Cryptococcus, Aspergillus

6. Pharmacology: Mechanism of action and side effects of the following drugs l Antipyretics and analgesics, Antibiotics, Antimalarial; Antikala-Azar,Antidiabetics l Antihypertensive, Antidiuretics, General and  cardiac vasodilators, Antiviral, Antiphrastic, Antifungal, Immunosuppressant’s l Anticancer

7. Forensic Medicine and Toxicology: Forensic examination of injuries and wounds; Examination of blood and seminal stains; poisoning, sedative overdose, hanging, drowning, burns, DNA and fingerprint study.

Paper-II

1. General Medicine: Etiology, clinical features, diagnosis, and principles of management (including prevention) of - Tetanus, Rabies, AIDS, Dengue, Kala-azar, Japanese Encephalitis.  Etiology, clinical features, diagnosis, and principles of management of Ischaemic heart disease, pulmonary embolism. Bronchial asthma.  Pleural effusion, tuberculosis, Malabsorption syndromes, acid peptic diseases, Viral hepatitis, and cirrhosis of the liver. Glomerulonephritis and pyelonephritis, renal failure, nephrotic syndrome, renovascular hypertension, complications of diabetes mellitus, coagulation disorders, leukemia, Hypo, and hyper thyroid, meningitis, and encephalitis. Imaging in medical problems, ultrasound, echocardiogram, CT scan, MRI. Anxiety and Depressive Psychosis and schizophrenia and ECT.

2. Pediatrics: Immunization, Baby-friendly hospital, congenital cyanotic heart disease, respiratory distress syndrome, broncho-pneumonias, kernicterus. IMNCI classification and management, PEM grading and management.  ARI and Diarrhea of under-five and their management.

3. Dermatology: Psoriasis, Allergic dermatitis, scabies, eczema, vitiligo, Steven Johnson’s syndrome, Lichen Planus.

4. General Surgery: Clinical features, causes, diagnosis, and principles of management of cleft palate, harelip. Laryngeal tumor, oral and esophageal tumors. Peripheral arterial diseases, varicose veins, coarctation of aorta Tumors of Thyroid, Adrenal Glands Abscess, cancer, fibroadenoma, and adenosis of breast.  Bleeding peptic ulcer, tuberculosis of bowel, ulcerative colitis, cancer stomach. Renal mass, cancer Prostate.  Haemothorax, stones of Gall bladder, Kidney, Ureter, and Urinary Bladder. Management of surgical conditions of Rectum, Anus and Anal canal, Gall bladder and Bile Ducts Splenomegaly, cholecystitis, portal hypertension, liver abscess, peritonitis, carcinoma head of the pancreas. Fractures of spine, Colles’ fracture, and bone tumors. Endoscopy Laparoscopic Surgery.

5. Obstetrics and Gynecology including Family Planning: Diagnosis of pregnancy. Labour management, complications of 3rd stage, Antepartum and postpartum hemorrhage, resuscitation of the newborn, Management of abnormal lie and difficult labor, Management of small for a date or premature newborn.  Diagnosis and management of anemia. Preeclampsia and Toxemias of pregnancy, Management of Post-Menopausal Syndrome. Intra-uterine devices, pills, tubectomy, and vasectomy. Medical termination of pregnancy including legal aspects. Cancer cervix. Leucorrhoea, pelvic pain, infertility, dysfunctional uterine bleeding (DUB), amenorrhea, Fibroid, and prolapse of uterus. 

6. Community Medicine (Preventive and Social Medicine): Principles, methods, approach, and measurements of Epidemiology Nutrition, nutritional diseases/disorders & Nutrition Programmes. Health information Collection, Analysis, and Presentation. Objectives, components, and critical analysis of National programs for control/ eradication of Malaria, Kala-azar, Filaria and Tuberculosis, HIV/AIDS, STDs, and Dengue Critical appraisal of Health care delivery system. Health management and administration: Techniques, Tools, Programme Implementation and Evaluation. Objective, Component, Goals, and Status of Reproductive and Child Health, National Rural Health Mission and Millennium Development Goals Management of hospital and industrial waste.